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4W15: Dynamics and molecular basis of post-translational modifications and cell signaling networks: Interdisciplinary approaches to understanding biological systems.




Post-translational modifications regulate various properties of proteins such as their activity, localization, stability, and interactions with other molecules, thereby playing a key role in the control of cell signaling networks and diverse biological processes. Recent advances in mass spectrometry, and in molecular, structural, and mathematical biology, have not only made it possible to identify novel post-translational modifications, but have also opened the door to a comprehensive understanding of the molecular basis and dynamics of protein modifications. It is now appreciated that spatio-temporal changes in post-translational modifications serve as the driving force in the dynamics of signal transduction pathways and underlie the diversity of cell responses. Furthermore, functional interplay between different modifications has recently been identified and is important for dictating cell-fate decisions. Perturbation of post-translational modifications is involved in a variety of life-threatening diseases. Therefore these modifications are also of clinical importance. In this workshop, speakers from various fields of biology, including molecular, structural, and mathematical biology, will present recent advances in the understanding of post-translational modifications (e.g. ubiquitination, sumoylation, glycosylation, acetylation, and phosphorylation) that regulate critical signaling pathways (e.g. NF-κB, MAPK, and Notch signaling). Furthermore, the use of an interdisciplinary approach to study signal transduction networks will be discussed.


14:00  井上純一郎(東大・医科研)
Identification of p47 as a negative regulator of NF-κB
14:17 市川一寿(東大・医科研)
Oscillation of transcription factor NF-κB: Causal function or inevitable consequence? An implication from computer simulations
14:33 大竹史明(東大・分生研)
Ubiquitin acetylation facilitates degradation of dioxin receptor
14:43 浦野健(島根大・医)
Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis
14:53 岡島徹也(名大・医)
Roles of a novel post-translational modification specific for epidermal growth factor domains
15:03 川崎政人(高エネ研)
Structural study of ubiquitin signaling in NF-κB pathway
15:13 石谷隆一郎(東大・理・生化)
Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition
15:29 武川睦寛(名大・環境医研)
A novel role of the stress-responsive MAP kinase pathways in regulation of the numeral integrity of centrosomes