Home > トピックス・イベント > 「修飾シグナル病」第1回国際シンポジウム



名称 文部科学省・科学研究費補助金・新学術領域研究
1st International Symposium on
Protein Modifications in Pathogenic Dysregulation of Signaling
会期 平成25年2月1日(金)、2日(土)
〒108-8639 東京都港区白金台 4-6-1[キャンパスマップ・交通案内]
参加費 無料
参加申込み 参加登録
お問い合せ 東京大学医科学研究所 分子発癌分野
〒108-8639 東京都港区白金台4-6-1
TEL: 03-5449-5275 FAX: 03-5449-5421
E-mail: symposium@shushoku-signal.com


お名前 (例:井上純一郎)
ご所属 (例:東京大学医科学研究所)


February 1st (Fri)

9:00-9:05 Opening remarks
Jun-ichiro Inoue
Session 1. Post-translational modifications in the regulation of NF-κB and related signaling I
Chairs: Jun-ichiro Inoue & Shoji Yamaoka
9:05-9:30 Jun-ichiro Inoue “Novel regulations of NF-κB pathway and their implication in cancer development”
9:30-10:20 Special Lecture 1
Shigeki Miyamoto
(University of Wisconsin Madison, USA)
“SUMOylation of NEMO in genotoxic NF-κB responses and its implication in cancer resistance”
Coffee Break
Session 2. Post-translational modifications in the regulation of NF-κB and related signaling II
Chairs: Fuminori Tokunaga & Yuji Yamanashi
10:40-11:05 Fuminori Tokunaga “Activation and regulation mechanisms of the linear ubiquitination-mediated NF-κB pathway”
11:05-11:30 Shoji Yamaoka “Role for A20 in cancer cell survival”
11:30-11:50 Fumihiko Okumura “Activation of double-stranded RNA-activated protein kinase (PKR) by interferon stimulated gene 15 (ISG15) modification down-regulates cap-dependent translation”
Session 3. Analysis of cellular signaling by structural biology and mathematical modeling
Chairs: Kazuhisa Ichikawa & Ryuichiro Ishitani
13:00-13:25 Ryuichiro Ishitani “Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation and lymphomagenesis”
13:25-13:45 Yusuke Sato “Structural basis for specific recognition of linear polyubiquitin chains by the NZF domain of HOIL-1L”
13:45-14:10 Kazuhisa Ichikawa “Computational simulation reveals critical 3D parameters that change oscillation pattern of nuclear NF-κB”
14:10-15:00 Special Lecture 2
Kwang-Hyun Cho
(KAIST, Korea)
"Puzzling switches in the signaling network of complex disease"
  Coffee break
Session 4. Post-translational modifications in the regulation of MAPK and related signaling
Chairs: Mutsuhiro Takekawa & Kohsuke Takeda
15:20-15:45 Mutsuhiro Takekawa “Regulation of human MAPK pathways and its failure in cancer”
15:45-16:35 Special Lecture 3
Francesc Posas (Universitat Pompeu Fabra, Spain)
"Control of gene expression and cell cycle progression by stress-activated protein kinases"
16:35-16:55 Kohsuke Takeda “Regulation of cellular stress response by mitochondrial protein phosphatase PGAM5”
16:55-17:15 Fumi Kano “Disease model cell system for analyzing the perturbation of signal transduction under disease condition”

February 2nd (Sat)

Session 5. Student and young scientist presentation
Chairs: Yasunori Saito & Taichiro Tomida
9:00-9:15 Hikari Yoshitane “JNK is a key regulator of circadian clock oscillator”
9:15-9:30 Toshiro Hara “Deletion of the Mint3 gene in mice abrogates macrophage functions and increases resistance to cancer metastasis”
Session 6. Regulation of PI3K-AKT signaling during cell fate decisions
Chairs: Masahide Takahashi & Jun-ichiro Inoue
9:30-9:55 Masahide Takahashi “Roles of the Akt substrate Girdin in cell motility”
9:55-10:45 Special Lecture 4
Alex Toker
(Harvard Medical School, USA)
“Specificity and Diversity in the PI 3-K and Akt Signaling Pathway in Cancer”
  Coffee Break
Session 7. Post-translational modification in cancer development
Chairs: Mutsuhiro Takekawa & Fuminori Tokunaga
11:05-11:25 Keiko Taguchi “Reciprocal activation between Nrf2 and a proliferative signaling in liver”
11:25-11:45 Kiyotsugu Yoshida “DYRK2 phosphorylation of c-Jun/c-Myc controls tumor progression by monitoring G1/S transition”
11:45-12:05 Ei ichiro Nishi “Nardilysin promotes cancer development through activation of ectodomain shedding”
Session 8. Proteomics approaches to elucidate signal transduction networks
Chairs: Masaaki Oyama & Shoji Yamaoka
13:30-13:55 Masaaki Oyama “Comprehensive description of cancer cell signaling networks by quantitative proteomics and systems biology”
13:55-14:45 Special Lecture 5
Blagoy Blagoev
(University of Southern Denmark, Denmark)
“Mapping the dynamics of phosphorylation and ubiquitination in signaling networks by quantitative proteomics”
14:45-15:05 Akihide Ryo “The peptidyl-p rolyl isomerase Pin1: a novel molecular switch for phosphorylation signaling”
  Coffee Break
Session 9. Post-translational modification in cell proliferation and differentiation
Chairs: Ryuichiro Ishitani & Atsushi Enomoto
15:25-15:45 Sanae M.M. Iguchi-Ariga “DJ-1 in cell transformation and neurodegenerative diseases”
15:45-16:05 Tohru Ishitani “Roles of two Ser/The kinases, NLK and Hipk2, in the regulation of Wnt/β-catenin signaling”
16:05-16:25 Hidemasa Goto “Novel mitotic signaling crosstalk between PI3K-Akt pathway and Plk1”
16:25-16:45 Yuji Yamanashi “Dok-7, Lrp4, and MuSK signaling in neuromuscular synaptogenesis”
16:45-16:50 Closing Remarks
Mutsuhiro Takekawa



JR山手線目黒駅東口から徒歩15分。 JR山手線目黒駅東口から都バス品93大井競馬場行で、白金台駅前下車。あるいは、都バス黒77千駄ヶ谷行または橋86新橋駅行で、 東大医科研病院西門下車。
東京メトロ日比谷線広尾駅そばの都バス広尾橋から黒77または橋86目黒駅行で、 東大医科研病院西門下車。