Home > トピックス・イベント > 「修飾シグナル病」第2回国際シンポジウム



名称 文部科学省・科学研究費補助金・新学術領域研究
2nd International Symposium on
Protein Modifications in Pathogenic Dysregulation of Signaling
会期 平成27年1月23日(金)、24日(土)
〒108-8639 東京都港区白金台 4-6-1[キャンパスマップ・交通案内]
参加費 無料
参加申込み 参加登録
ポスター PDF
PDF (1.5MB)
お問い合せ 東京大学医科学研究所 分子発癌分野
〒108-8639 東京都港区白金台4-6-1
TEL: 03-5449-5275 FAX: 03-5449-5421
E-mail: symposium@shushoku-signal.com


お名前 (例:井上純一郎)
ご所属 (例:東京大学医科学研究所)


January 23 (Fri)

Opening remarks
9:30-9:35 Jun-ichiro Inoue
Session 1. Post-translational modifications in the regulation of NF-κB and related signaling I
(Chairs: Jun-ichiro Inoue & Kazuhisa Ichikawa)
9:35-10:00 Jun-ichiro Inoue “The role of ubiquitin ligase TRAF6 in osteoclastogenesis”
10:00-10:50 Seok Hee Park (Sungkyunkwan University, Korea) Special Lecture 1
“Distinct Roles of A20 ubiquitin editing enzyme in TGF-β signaling pathway”
Coffee Break (20 min)
Session 2. Post-translational modifications in the regulation of NF-κB and related signaling II
(Chairs: Fuminori Tokunaga & Mutsuhiro Takekawa)
11:10-11:35 Fuminori Tokunaga “Linear ubiquitination-mediated NF-κB regulation”
11:35-12:25 Shao-Cong Sun
(University of Texas, MD Anderson Cancer Center, USA)
Special Lecture 2
“Regulation of noncanonical NF-kB signaling by ubiquitination”
Lunch (65 min)
Session 3. Analysis of cellular signaling by structural biology
(Chairs: Ryuichiro Ishitani & Masaaki Oyama)
13:30-13:55 Ryuichiro Ishitani ”Structural basis for catalytic mechanisim of DncV, bacterial homologue of cyclic GMP-AMP synthase”
13:55-14:15 Masaki Mishima “Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation”
14:15-14:35 Yusuke Sato “Structural basis for specific cleavage of M1- and K63-linked polyubiquitin chains by the CYLD deubiquitinase”
Coffee break (20 min)
Session 4. Regulation of cellular functions by post-translational modifications
(Chairs: Masahide Takahashi & Hirofumi Kai)
14:55-15:15 Takeshi Endo “Signal transduction mechanisms regulating myofibrillogenesis and alveolarization”
15:15-15:35 Tomotake Kanki “The signaling pathway regulating mitochondria autophagy”
15:35-15:55 Tatsuya Saitoh “Regulation of innate immune response by post-translational modifications”
Coffee break (20 min)
Session 5. Mathematical simulation of signal transduction
Chairs: Kazuhisa Ichikawa & Hiroyuki Kubota)
16:15-16:40 Kazuhisa Ichikawa “How is the oscillation of nuclear NF-κB regulated?”
16:40-17:30 Savas Tay
(ETH Zürich, Switzerland)
Special Lecture 3
“Noise facilitates NF-κB entrainment and transcriptional control under complex signalling inputs”
17:30-17:50 Hiroyuki Kubota “Reconstruction of insulin signal flow from phosphoproteome and metabolome data”

January 24 (Sat)

Session 6. Student and young scientist presentation
(Chairs: Atsushi Enomoto & Taichiro Tomida)
9:00-9:15 Atsushi Uematsu “Identification of a novel E3 ligase for deubiquitination enzyme CYLD.”
9:15-9:30 Kentaro Kajiwara “Spatiotemporal regulation of Src in epithelial morphogenesis”
Session 7. Dysregulation of post-translational modifications in human diseases
(Chairs: Jun-ichiro Inoue & Fuminori Tokunaga)
9:30-9:55 Shoji Yamaoka “A20 interacts with Caspase-8 and FADD to protect adult T-cell leukemia cells”
9:55-10:15 Hirofumi Kai “Podocyte-p53 is essential to control the progression of hereditary renal disease Alport syndrome”
10:15-10:35 Akio Kihara “Regulation of fatty aldehyde dehydrogenases by lipid modification”
Coffee Break (20 min)
Session 8. Post-translational modifications in the regulation of MAPK signaling
(Chairs: Mutsuhiro Takekawa & Takeshi Endo)
10:55-11:20 Mutsuhiro Takekawa “MCRIP1, a novel ERK substrate, mediates ERK-induced epigenetic gene silencing during epithelial-to-mesenchymal transition”
11:20-12:10 Bin Zheng
(MGH, Harvard Medical School, USA)
Special Lecture 4
“Crosstalk between BRAF-MEK-ERK and LKB1-AMPK Signaling pathways and its therapeutic implications “
12:10-12:30 Kazuhiro Aoki “Quantitative analysis of ERK signaling with live cell imaging”
Lunch(70 min)
Session 9. Regulation of AKT signaling during cell fate decisions
(Chairs: Masahide Takahashi & Yuji Yamanashi)
13:40-14:05 Masahide Takahashi “Akt/girdin signaling in cancer progression”
14:05-14:55 John Blenis
(Weill Cornell Medical College, USA)
Special Lecture 5
“mTORC1 targets, metabolism and cancer.”
14:55-15:15 Junko Sasaki “The novel mechanism of tumor suppression by INPP4B”
Coffee Break (20 min)
Session 10. Proteomics approaches to elucidate signal transduction networks
(Chairs: Masaaki Oyama & Tatsuya Sawasaki)
15:35-16:00 Masaaki Oyama “High-resolution phosphoproteomics defines regulation of cancer cell signaling”
16:00-16:20 Kazuo Yamamoto “A novel method to identify O-GlcNAcylated proteins using a soluble N-acetylgalactosaminyltransferase
16:20-16:40 Tatsuya Sawasaki “Polyubiquitin-chain interactome by cell-free human protein array”
Closing Remarks
16:40-16:45 Mutsuhiro Takekawa


JR山手線目黒駅東口から徒歩15分。 JR山手線目黒駅東口から都バス品93大井競馬場行で、白金台駅前下車。あるいは、都バス黒77千駄ヶ谷行または橋86新橋駅行で、 東大医科研病院西門下車。
東京メトロ日比谷線広尾駅そばの都バス広尾橋から黒77または橋86目黒駅行で、 東大医科研病院西門下車。